Cisplatin atherosclerosis
WebTherefore, selective inhibition of CaMKIIγ in lesional macrophages holds great promise for the treatment of advanced atherosclerosis. We recently developed a siRNA NP platform that can selectively silence CaMKIIγ in macrophages, resulting in increased plaque stability.
Cisplatin atherosclerosis
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WebModern hypotheses introduce atherosclerosis as an inflammatory/lipid-based disease and NLRP3 inflammasome has been considered as a link between lipid metabolism and inflammation because crystalline cholesterol and oxidized low-density lipoprotein (oxLDL) (two abundant components in atherosclerotic plaques) activate NLRP3 inflammasome. WebRecently, a genome-wide analysis of cisplatin-induced peripheral neuropathy in survivors of adult-onset cancer reported that genetically determined expression level of RPRD1B …
WebCisplatin is also used alone or in combination with other medications to treat bladder cancer that can not be treated with surgery or radiation therapy alone. Cisplatin is in a class of … WebDec 30, 2024 · However, cardiovascular toxicity is a major concern. In addition to acute endothelial toxicity and associated risk of arterial thrombosis, accelerated atherosclerosis may be the result of chemotherapy-associated latent cardio-metabolic dysfunction. A 45-year-old man began treatment with cisplatin-based chemotherapy for testicular cancer.
WebApr 14, 2024 · Histone acetylation plays a vital role in organizing chromatin, regulating gene expression and controlling the cell cycle. The first histone acetyltransferase to be identified was histone acetyltransferase 1 (HAT1), but it remains one of the least understood acetyltransferases. HAT1 catalyzes the acetylation of newly synthesized H4 and, to a … WebNational Center for Biotechnology Information
WebIn addition, BANCR induced the proliferation of vascular smooth muscle cells by downregulating miR-34c methylation in atherosclerosis. 34 Here, we could not exclude the possibility that BANCR may attenuate the killing capacity of cisplatin on GC cells by regulating miRNAs. Further investigation is needed in our future study.
WebAug 14, 2024 · Lipopolysaccharide (LPS) is an endotoxin that induces systemic inflammatory responses. Melittin, a main constituent of bee venom, exerts several biological activities such as antioxidant, anti-inflammatory, and antiapoptotic actions. However, whether melittin protects against endotoxin-induced AKI remains undetermined. greenlaws campground maineWebStatins were associated with slower progression of overall coronary atherosclerosis volume, with increased plaque calcification and reduction of high-risk plaque … greenlaws campground stonington maineWebJun 27, 2014 · A 52-year-old executive was referred to our clinic for risk factor management after undergoing coronary computed tomography angiography (CTA) as part of an … green law solicitors limitedWebQuick Search anywhere. Enter Search Terms Search. Quick Search in Journals flyfly hobby bae hawkWebSep 1, 2024 · Cohort 1: Early effects of cisplatin-based chemotherapy Vascular function Participant characteristics are presented in Table 1. %FMD decreased 24 h after the first dose of cisplatin in the 10 patients managed with 3 to 4 cycles of BEP (16.7 ± 1.6 at baseline vs. 10.9 ± 0.9 at 24 h after cisplatin; p = 0.003) ( Figure 2 ). greenlaws campgroundWebJul 1, 2016 · Nephrotoxicity is a well documented adverse effect of cisplatin use, with a dose-dependent and irreversible reduction in renal function. 75, 76, 77 Possible mechanisms include endothelial and epithelial cell damage and dysfunction. 78 Patients treated with cisplatin-based chemotherapy have a high prevalence of microalbuminuria … greenlaw stationWebDec 30, 2024 · Cisplatin causes direct and acute endothelial toxicity with a propensity to arterial thrombosis, irrespective of the presence of underlying atherosclerosis. … greenlaws music inc